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Thiamidol powder

Name: Thiamidol powder
Brand: Joyous Pellets Supplement raw materials, cosmetic ingredients, weight loss ingredients, organic protein powder, fruit and vegetable powder, GABA, fisetin
Availability: InStock
Rating: 5 (1 reviews)

The full name of Thiamidol is N-(4-(2,4-Dihydroxyphenyl)thiazol-2-yl)isobutyramide. It is the most powerful ingredient that inhibits human tyrosinase Mars so far. The activity of Thiamidol is 120 times that of 377 and 450 times that of kojic acid. times, and in addition to whitening, Thiamidol’s effect on chloasma is also very obvious

Product Name

Thiamidol

Appearance

Light yellow to white powder

Specification

98%

CAS No

1428450-95-6

Molecular Formula

C13H14N2O3S

Package

25kg cardboard drum

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Desciption

Product information
What is Thiamidol?
From 2018 to 2021, Beiersdorf published three heavyweight articles. They used recombinant human tyrosinase to screen out the component with the strongest inhibitory effect on human tyrosinase activity from a library of 50,000 compounds so far— —Isobutylamidothiazolylresorcinol (Thiamidol for short), and has applied for a patent (Chinese patent number is CN105007991A), known as the strongest whitening ingredient in history.
Joyous Thiamidol powder specification

Terms	Standard	Terms	Standard
Product Name	Thiamidol	Appearance	Off white powder
Assay	98%	Loss on Drying	≤2%
Total Heavy Metals	≤10 ppm	Ash	≤2%
As	≤0.5ppm	Total Plate Count	≤750 cfu/g
Pb	≤0.5ppm	Yeast and Mold	≤100 cfu/g
Cd	≤0.5ppm	Coliforms	Negative
Hg	≤0.1ppm	E.Coli	Negative
Packing	Pack in 25kgs paper-drums, inner by double plastic bag	Shelf life	24 months under the above condition, and in its original package

The relationship between Thiamidol and tyrosinase
Thiamidol is also a tyrosinase inhibitor. Like all resorcinol-based whitening agents, Thiamidol is also a tyrosinase inhibitor. And if we want to understand whitening clearly, we must first understand tyrosinase.
Currently, it is known that there are three types of melanin in the human body: eumelanin, pheomelanin, and neuromelanin. Neuromelanin has nothing to do with the skin, so we generally only discuss eumelanin and pheomelanin. Melanin is a defense mechanism developed during the evolution of life to avoid damage to the body from sunlight, inflammation, etc. The main functions are antioxidant, free radical scavenging (melanin contains many conjugated groups and polyphenol structures, and has a good ability to annihilate free radicals), and radiation protection (melanin can increase the survival rate and repair ability under X-rays and nuclear radiation) ), thermal regulation, etc. The structure of melanin is extremely complex, and people have not fully understood it yet. Only some of the groups contained in melanin are known through disassembly.
The current mainstream understanding of the melanin production pathway is the Raper-Mason pathway: the biosynthesis of melanin (eumelanin) begins with tyrosine, which is oxidized by oxygen or catalyzed by tyrosinase to form levodopa. (L-DOPA), to dopaquinone. Intramolecular nucleophilic addition of amines to quinones yields 5,6-dihydroxyindole-2-carboxylic acid (DHICA), which is then spontaneously decarboxylated to yield 5,6-dihydroxyindole (DHI). These subunits interact and may assemble into multimers and stacks of planar tetramers, pentamers, or hexamers, and these secondary structures aggregate to form larger amorphous structures. Phaeomelanin is synthesized in the presence of cysteine or glutathione and levodopa under the action of tyrosinase.
Although the true structure of melanin and its synthesis process in the body are not yet fully understood, the role of tyrosinase in the production of melanin is unquestionable. Scientists also use tyrosinase during the synthesis process in vitro. Catalysis, so inhibiting tyrosinase activity is a really effective way.
How powerful is Peptide Amido as the most powerful whitening agent?
In order to more realistically reflect the effect on human skin, Beiersdorf used human tyrosinase model (hTyr) instead of mushroom tyrosinase (mTyr) when it was first released. Since commercial hTyr is extremely rare, Currently, mTyr is used in experiments to test tyrosinase activity inhibition on the market. However, mTyr has a different amino acid sequence and structure in the active site region than hTyr, so the reference significance is not very great. Beiersdorf used recombinant technology to obtain human tyrosinase and compared the effects of commonly used whitening ingredients on the market, such as 4-butylresorcinol, 377, arbutin, and hydroquinone. The IC50 value (concentration that inhibits half of the enzyme activity) of peptide amine midon on hTyr is 1.1uM (uM is the unit of molar concentration, representing umol/L), which shows that it can strongly inhibit the activity of hTyr, but only weakly inhibit mTyr (IC50 Value is 108uM). Judging from the hTyr inhibition data alone, the activity of peptide amine middot is 20 times that of 4-butylresorcinol and 120 times that of 377. Of course, Beiersdorf also conducted skin model testing, which showed that peptide amine midol is 15 times more powerful than 4-butylresorcinol and 450 times more powerful than kojic acid.
The effect of peptide Amido on chloasma
In 2019, Beiersdorf compared 0.2% peptidamide with 2% hydroquinone (hydroquinone is the gold standard for the treatment of chloasma). The effect of peptidamine was very obvious, regardless of low ultraviolet or ultraviolet radiation. It has the same performance in high UV environment, and the effect is better than hydroquinone (Figure 5). After 12 weeks of application, melasma has been significantly reduced, and the skin's brightness and whiteness have been significantly improved.
Therapeutic effect of peptide Amido on post-inflammatory pigmentation
In 2021, Beiersdorf, who was running wild, published a third article, about the therapeutic effect of peptide amido on post-inflammatory hyperpigmentation (PIH).
PIH causes dark marks on the skin after the skin is exposed to trauma or inflammation, which greatly affects the appearance. The specific cause of PIH is currently unknown. Simply using anti-inflammatory ingredients cannot prevent the occurrence of pigmentation.
Peptidemidol can inhibit human tyrosinase activity very efficiently and is also used by Beiersdorf to treat post-inflammatory pigmentation. According to the results of the article, the same use of 0.2% peptidamine can effectively improve the pigmentation caused by acne, and obvious effects can be seen in the second week. In addition, 0.1% concentration of peptidamine is used clinically to reduce the appearance of age spots.
Safety of Peptide Amido
Beiersdorf compared its effect with hydroquinone. Peptidemidol can quickly reduce melanin production in melanocytes, and then remove the effect. Melanin production will quickly recover, but the cells affected by hydroquinone cannot return to their original activity. State, it has also been confirmed that hydroquinone has a certain poisoning effect on melanocytes.

Finally, Beiersdorf also marked the action site model of peptide amine midon and tyrosinase in the article, allowing us to better understand why this raw material has such a strong hTyr inhibitory ability (peptide amine midon and tyrosinase) Tyrosine competes for tyrosinase, and its binding sites with tyrosinase are many and very close, which is why its tyrosinase inhibitory activity is stronger than other whitening agents).
Package and delivery

Delivery
1-80kg	80-300kg	More than 300kg
More suitable for express transportation, door-to-door	More suitable for air transportation,airport-to-airport	More suitable for ocean transportation,port-to-port
7-10 days for delivery time	3-4 days for delivery time	20-40 days for delivery time

What service we can provide
Joyous Health provides Thiamidol powder OEM services. We can customize formulas for customers, private labels, capsules, tablets, soft capsules and sachets, low MOQ, which is suitable for direct sales by brands. Our OEM product shipping channels are stable and delivery times are fast and worthy of customers' trust, we have served more than 300 brands.

Joyous Health Factory information and certifications
Xi'an Joyous Health Biotechnology Co., Ltd. was established in 2011. Over the past 12 years, Joyous Health has obtained ISO 9001, FDA, ISO 22000, and GMP certifications.
Joyous Health has an advanced laboratory to control quality, so that each batch of products undergoes strict testing, and has professional R&D personnel to provide customized product services.
For more details please click here

Where to buy Thiamidol powder?
We offer the best Thiamidol powder at the most competitive price.Thiamidol Powder bulk and wholesale powder have been 3rd lab-tested and verified for both product purity and identity.
We also provide Thiamidol powder in bulk order or wholesale according to client needs. Just submit the requirements in the bottom form, we will reply soon!

Contacts: Faith Feng
Email:[email protected]
Tel and Whatsapp:+86 17391747738

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Contact: Xi'an international enterprise center B building, Fengcheng 4 road, Xi'an City, Shaanxi province, China; [email protected]; +86 17391747738

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