Rhizoma Zingberis Preparata,DMF,5,7-DIMETHOXYFLAVONE,Black ginger polymethyl flavone,Black ginger powder,Black ginger extract,Black ginger Manufacturer

Polymethoxylated flavonoids are the main active ingredients of black ginger extract and are one of the popular weight loss ingredients in the Japanese market. Studies have confirmed that black ginger polymethoxylated flavonoids can promote metabolism and blood circulation, thereby achieving the effect of weight loss; in addition, it can also maintain the walking ability of middle-aged and elderly people who gradually decline due to age. According to statistics, a total of 82 functional foods containing this ingredient were approved in 2021.

Product Name

Black ginger polymethyl flavone

Plant Source

Zingiber officinale Rosc.

CAS No.

1036-72-2

Specification

1% 5,7-DIMETHOXYFLAVONE

Other Names

DMF,5,7-dimethoxyflavone

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Desciption

Product information
What is Black ginger extract powder?
The rhizome of black ginger has been traditionally used as food and folk medicine in Thailand for more than 1,000 years. In the old days, it was a royal tribute. This is why Zheng He paid tribute to black ginger to the emperor of the Ming Dynasty. In some parts of Southeast Asia, especially in Thailand, people slice black ginger and boil it in water to drink it as tea. They also soak it in wine and drink it as medicinal wine.
Black ginger is quite different from ordinary ginger plants in that it is smaller in size, has a long growth cycle of 10 months, and is dark purple in color. Black ginger is rich in active ingredients such as polymethoxyflavonoids, zinc, arginine, and anthocyanins. Among them, the content of "polymethoxyflavonoids" is relatively high. Its main functions include antioxidant, vasodilation, and anti-allergy. , is used in the manufacturing of food, cosmetics and pharmaceuticals.

Black ginger rhizomes are rich in flavonoids, of which 32 have been reported so far. The main active substances are 5, 7-dimethoxyflavonoids and polymethoxyflavonoids (PMFs). The flavonoid content of black ginger rhizomes varies due to different measurement methods and also varies from place to place. Sutthanut et al. established a gas chromatography method for determining the content of black turmeric compounds. They also analyzed the content of black turmeric compounds from different origins in Thailand. The results showed that the content of different origins varied greatly, with the lowest being 23.86 mg/g. The highest is 60.98 mg/g. In addition, as a health food, black ginger rhizome extract should have a standardized content of 5, 7-dimethoxyflavanones of not less than 2.5% and a total PMFs content of not less than 10%.
In addition to flavonoids, a variety of other compounds have been isolated from black ginger rhizomes, including glycosides, phenolic glycosides, glycerol, esters, anthraquinones, sterols, etc. The glycoside content is 0.016 83% and the phenolic glycosides are approximately 0.004 8%. . Among them, 3 glycosides have been reported in analysis, 6 are phenolic glycosides, 3 are glycerol, and others include 1-O-β-glucopyranosyl-8Z-2-(2′-hydroxytetracarboacylamino)- 8-Octadecane-1, 3, 4-triol, β-sitosterol myristate, 9Z, 12Z-linoleic acid methyl ester, (1E, 6E)-1, 7-diphenyl-1, 6-Heptadiene-3, 5-dione, adenosine, l-phenylalanine, 2-methoxyanthraquinone, 2-hydroxy-9, 10-anthraquinone, β-sitosterol and carotene, etc. compound.

Joyous Turkestrone powder specification

Terms	Standard	Terms	Standard
Product Name	5,7-DIMETHOXYFLAVONE	Appearance	Brown powder
Assay	0.5%,1%,2%	Loss on Drying	≤2%
Total Heavy Metals	≤10 ppm	Ash	≤2%
As	≤0.5ppm	Total Plate Count	≤750 cfu/g
Pb	≤0.5ppm	Yeast and Mold	≤100 cfu/g
Cd	≤0.5ppm	Coliforms	Negative
Hg	≤0.1ppm	E.Coli	Negative
Packing	Pack in 25kgs paper-drums, inner by double plastic bag	Shelf life	24 months under the above condition, and in its original package

What are the functions and effects of Black ginger extract?
1 Anti-tumor effect
Black ginger has historically been used to treat various ailments including cancer. Early studies reported that black ginger extract is cytotoxic to different leukemia cells and cancer cells, but its molecular mechanism of action remains unclear. Black ginger ethanol extract has an inhibitory effect on the cell viability, cell migration, cell invasion, cell apoptosis, cell survival and growth-related signaling pathways of human cervical cancer cells (HeLa), revealing its anti-tumor activity. Bhardwaj et al. used supercritical carbon dioxide fluid extraction of black ginger rhizome to obtain 5-hydroxy-7-methoxyflavone, which can regulate the mitochondria-mediated apoptosis signaling pathway in human colon cancer HCT-116 cells through reactive oxygen species (ROS). expression to induce apoptosis, indicating that black ginger can be used for targeted therapy of colon cancer. Wong-srikaew et al. reported that the supercritical carbon dioxide extract of black ginger rhizome showed a stronger anti-proliferative effect on human cervical cancer cells and adenocarcinoma cells than the ethanol extract. Through principal component analysis, it was concluded that 5, 7-dimethoxyflavone Is an effective anti-cancer ingredient. Hossain et al. used supercritical carbon dioxide extraction to analyze compounds in black ginger rhizomes. The results showed that the rhizomes contained 3, 5, 7, 4'-tetramethoxyflavone, 5, 7, 4'-trimethoxyflavone and 5-hydroxy. -3, 7, 3′, 4′-Tetramethoxyflavone can induce the death of human colon cancer HCT-15 cells through the apoptosis pathway, and it may be used as a new anti-cancer drug. Paramee et al. [43] studied the ovarian cancer cell line SKOV3 and showed that cells treated with black ginger extract showed DNA fragmentation and malformation, and the phosphorylation of protein kinase B (AKT) and extracellular regulated protein kinase ERK1/2 was reduced. It may exhibit anti-tumor activity by inducing cell apoptosis through the PI3K/AKT and MAPK signal transduction pathways.

2. Enhance male sexual performance
Black ginger has long been used to enhance male sexual performance. Sudwan et al. reported that oral administration of 240 mg/kg black ginger extract can shorten the courtship behavior time of mice within the first 10 minutes. Chaturapa-nich et al. reported that black ginger hexane and water extracts had no effect on male sexual behavior, while ethanol extract could significantly increase testicular blood flow and have an aphrodisiac effect. Temkitthawon et al. reported that the ethanol extract of black ginger rhizome has a high content of active ingredients that inhibit PDE5 and PDE6 and can be used to treat male erectile dysfunction. This provides more favorable evidence that black ginger enhances male ability. Wannanon et al.'s research showed that although black ginger extract had no significant effect on sex hormone levels in elderly healthy men, it showed significant changes in penile erection length and sexual desire stimulation response latency. It is believed that black ginger can be used to treat erectile dysfunction in elderly men. Lert-Amornpat et al. reported that although black ginger powder suspension had no significant effect on the body weight, blood sugar, and food intake of streptozotocin (STZ)-induced diabetic rats, its sexual behavior and serum testosterone levels significantly recovered, indicating that black ginger powder suspension Ginger has the effect of improving sperm density, testosterone levels and sexual function in diabetic rats. These provide some evidence that black ginger extract can enhance male sexual performance.

3. Anti-inflammatory effect
Tewtrakul et al. isolated 5-hydroxy-3, 7, 3′, 4′-tetramethoxyflavone from the ethyl acetate extraction layer of black ginger rhizome ethanol extract, which has significant anti-inflammatory activity. Sae-Wong et al. reported that 5-hydroxy-3, 7, 3′, 4′-tetramethoxyflavone is the main anti-inflammatory active compound in black ginger ethanol extract, which can inhibit inducible nitric oxide synthase ( iNOS) messenger ribonucleic acid (mRNA) expression to achieve anti-inflammatory effects. Sae-Wong et al. also reported that 5, 7-dimethoxyflavone, trimethylapigenin and 3′, 4′, 5, 7-tetramethoxyflavone in the chloroform extract of black ginger rhizome had an effect on iNOS mRNA and iNOS protein expression has a strong inhibitory effect. Horigome et al. reported that 5, 7-dimethoxyflavone and 5-hydroxy-3, 7, 3′, 4′-tetramethoxyflavone in n-hexane extract of black ginger can significantly inhibit mast cell degranulation and inflammatory mediators. production and expression of mRNA. Rujjanawate et al. reported that oral administration of black ginger ethanol extract can inhibit the formation of gastric ulcers and thereby protect the stomach. Jin et al. reported that ethanol extract of black ginger rhizome can inhibit the expression of iNOS, cyclooxygenase-2 (COX-2) and tumor necrosis factor (TNF)-α, and significantly reduce the nuclear factor in mononuclear macrophages RAW264.7 Phosphorylation of inhibitory κB protein α (IκBα) and nuclear factor κB (NF-κB) and nuclear transport ability of p65. Lee et al. reported that ultraviolet rays increased the expression of COX-2, while ethanol extract of black ginger rhizome could reduce the expression of COX-2 in mouse skin tissue, indicating that black ginger extract has anti-inflammatory effects.

4 Improve athletic ability
NO plays an important role in enhancing the physical fitness of sports participants, so sports supplements that promote NO production have received widespread attention in the field of sports nutrition. Fitnox is a mixture of black ginger methoxyflavonoids, pomegranate peel polyphenols and total saponins of Moringa oleifera leaves. The test showed that the levels of nitrate NO3- and nitrite NO2- in the serum and saliva of healthy adult men who took 250 mg Fitnox capsules were significantly reduced. Higher than the placebo group, and NO3– and NO2– can be converted into NO through different pathways, so Fitnox can improve the overall performance and physical endurance of exercise participants. Kim et al. reported that black ginger rhizome ethanol extract can improve exercise capacity by regulating the expression of transcription factors in mitochondrial synthesis and activating signal transduction pathways such as sirtuin 1. Wattana-thorn et al. reported that taking 25 or 90 mg black ginger extract once a day for 8 weeks, healthy elderly volunteers showed an improvement in their ability to sit up in a chair in 30 seconds and walk in 6 minutes, so it can be used as a supplement for the elderly. Health supplements. However, Wasuntarawat et al. reported that taking capsules containing black ginger failed to improve exercise capacity and endurance. Therefore, the conduction pathways and mechanisms by which black ginger improves exercise capacity are still unclear.

2.5 Antioxidant effect
The flavonoids and terpenoids contained in black ginger rhizomes have good antioxidant activity. Wungsintaweekul et al.'s study showed that when the maximum inhibitory concentration (IC50) of black ginger methanol extract is 61.5 mg/mL, it shows strong antioxidant activity. In addition, the flavonoids 3, 5, 7, 3′, 4′-pentamethoxyflavone and 5, 7, 4′-trihydroxytrimethoxyflavone in black ginger extract have strong anti-glycation properties Active, can be used to fight diabetes and reduce the harm caused by oxidative stress.

2.6 Antifungal effect
When the concentration of crude ethanol extract of black ginger is 1%, it can effectively inhibit the germination of spores of red star pathogen by 55%. The 3, 5, 7-trimethoxyflavone in the ethanol extract of black ginger rhizome also showed high activity against Trichophyton rubrum, Trichophyton mentagrophytes and Trichophyton gypsum, with a minimum inhibitory concentration (MIC) of 250 μg/mL. 5, 7, 3′, 4′-tetramethoxyflavone and 5, 7, 4′-trimethoxyflavone in black ginger have anti-Candida albicans activity [13], with IC50 of 39.71 and 17.63 mg/mL respectively. .

2.7 Antiviral effect
Sornpet et al. reported that ethanol and water extracts of black ginger rhizome have significant anti-H5N1 influenza virus activity. Sookkongwaree et al. reported that 5-hydroxy-7-methoxyflavone and 5, 7-dimethoxyflavone in the methanol extract of black ginger rhizome can inhibit the activity of human immunodeficiency virus HIV-1 protease, with an IC50 of 19 mmol/L; 5-Hydroxy-3, 7-dimethoxyflavone can inhibit the activities of hepatitis C virus HCV protease and human cytomegalovirus HCMV protease, with IC50 of 190 and 250 mmol/L respectively.

2.8 Neuroprotective effect
Wattanathorn et al. reported that ethanol extract of black ginger rhizome has neuroprotective and stress-relieving effects. Welbat et al. orally administered black ginger ethanol extract to male mice for 21 days. The results showed that black ginger extract could prevent valproic acid-induced cognitive impairment in the mouse brain and reduce hippocampal neurogenesis, indicating that it has antidepressant effects. In addition, the main flavonoids in black ginger rhizome extract (5, 7-dimethoxyflavone, 5, 7, 4′-trimethoxyflavone and 3, 5, 7, 3′, 4′-penta Methoxyflavonoids) have specific and selective inhibitory effects on β-secretase BACE1, but have no inhibitory effect on α-secretase or other serine protease activities. Therefore, black ginger extract can be used as a natural inhibitor of β-secretase. agent, which may serve as a new treatment to prevent Alzheimer's disease.

2.9 Vasodilation and cardiovascular protection
Black ginger extract has the ability to treat cardiovascular disease and anti-hypertension. Yorsin et al. [64] reported that the methylene chloride extract of black ginger can promote the expression of endothelial nitric oxide synthase (eNOS) and the production of NO. Wattanpitayakul et al. reported that ethanol extract of black ginger can promote phenylephrine- and acetylcholine-induced relaxation of the aortic ring and ileum in rats. Malakul et al. have shown that ethanol extract of black ginger reduces ischemia-reperfusion injury I/R by activating the cGMP-NO pathway, weakening calcium ion influx and ROS in the aortic ring of rats, thereby achieving cardiac protection.

2.10 Transdermal penetration promotion effect
Most of the methoxyflavonoids in black ginger extract have the characteristics of low molecular weight, low oil-water partition coefficient logP and low melting point, and have good transdermal penetration-promoting effects. In addition, the methylene chloride extract of black ginger can be made into solid lipid nanoparticles, thereby improving transdermal permeability. The ratio of 15% black ginger extract, 3% oleic acid and 3% menthol can enhance the osmotic activity of methoxyflavonoids in mice.

2.11 Other functions
In a mutagenic study of Salmonella typhimurium TA98 strain using the mutagen Trp-P-2, it was found that 5, 7-dimethoxyflavone and 5, 3-dihydroxy-3 in black ginger rhizome extract , 7, 4′-trimethoxyflavone, 3, 5, 7-trimethoxyflavone and 5-hydroxy-7-methoxyprogesterone have antimutagenic activity, with IC50 of 0.40, 0.42, 0.47 and 0.40 nmol/ respectively. plate. Black ginger extract also has anti-allergic, anti-obesity, and anti-osteoarthritis effects.

Package and delivery

Delivery
1-80kg	80-300kg	More than 300kg
More suitable for express transportation, door-to-door	More suitable for air transportation,airport-to-airport	More suitable for ocean transportation,port-to-port
7-10 days for delivery time	3-4 days for delivery time	20-40 days for delivery time

What service we can provide
Joyous Health provides Black ginger extract powder OEM services. We can customize formulas for customers, private labels, capsules, tablets, soft capsules and sachets, low MOQ, which is suitable for direct sales by brands. Our OEM product shipping channels are stable and delivery times are fast and worthy of customers' trust, we have served more than 300 brands.

Joyous Health Factory information and certifications
Xi'an Joyous Health Biotechnology Co., Ltd. was established in 2011. Over the past 12 years, Joyous Health has obtained ISO 9001, FDA, ISO 22000, and GMP certifications.
Joyous Health has an advanced laboratory to control quality, so that each batch of products undergoes strict testing, and has professional R&D personnel to provide customized product services.
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Where to buy Black ginger extract powder?
We offer the best Black ginger extract powder at the most competitive price. Black ginger extract Powder bulk and wholesale powder have been 3rd lab-tested and verified for both product purity and identity.
We also provide Black ginger extract powder in bulk order or wholesale according to client needs. Just submit the requirements in the bottom form, we will reply soon!

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