Nicotinamide adenine dinucleotide powder,NADH best price,NADH manufacturer

NADH (Nicotinamide adenine dinucleotide) is a chemical substance, generally refers to reduced coenzyme I, which is the reduced state of nicotinamide adenine dinucleotide. N refers to nicotinamide, A refers to adenine, and D is dinucleotide.

Product Name

Nicotinamide adenine dinucleotide

Specification

Reduced state

CAS No.

606-68-8

Chemical Formula

C21H27N7O14P2

Appearance

White powder

Molecular Weight

663.41

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Desciption

Product information
What is NADH powder?
NADH (Nicotinamide adenine dinucleotide) is a chemical substance, generally refers to reduced coenzyme I, which is the reduced state of nicotinamide adenine dinucleotide. N refers to nicotinamide, A refers to adenine, and D is dinucleotide.
Because NADH is mainly involved in material and energy metabolism in cells, it is produced in the citric acid cycle in glycolysis and cellular respiration, and serves as a carrier and electron donor for biological hydrogen. It is transferred through the oxidative phosphorylation process on the inner mitochondrial membrane. Energy supplies ATP synthesis, so NADH is also called mitochondrial hormone. Theoretically, the energy released by 1 molecule of NADH can synthesize 2.5 molecules of ATP.
NADH plays an important role in maintaining cell growth, differentiation and energy metabolism, as well as cell protection.
NADH is produced in the citric acid cycle during glycolysis and cellular respiration. The NADH molecule is a control marker in the energy production chain in mitochondria. Monitoring the redox status of NADH is the best parameter to characterize mitochondrial function in vivo. Ultraviolet light can excite NADH in mitochondria to produce fluorescence, which can be used to monitor mitochondrial function.
Joyous Turkestrone powder specification

Terms	Standard	Terms	Standard
Product Name	Nicotinamide adenine dinucleotide（NADH）	Appearance	White powder
Assay	99%	Loss on Drying	≤2%
Total Heavy Metals	≤10 ppm	Ash	≤2%
As	≤0.5ppm	Total Plate Count	≤750 cfu/g
Pb	≤0.5ppm	Yeast and Mold	≤100 cfu/g
Cd	≤0.5ppm	Coliforms	Negative
Hg	≤0.1ppm	E.Coli	Negative
Packing	Pack in 25kgs paper-drums, inner by double plastic bag	Shelf life	24 months under the above condition, and in its original package

Some brief introduction to NADH.
NADH and NAD+ are a redox pair in cells. NADH is the reduced form of coenzyme NAD+, and NAD+ is its oxidized form. In the redox reaction, NADH serves as the donor of hydrogen and electrons, and NAD+ serves as the acceptor of hydrogen and electrons, participating in physiological processes such as respiration, photosynthesis, and alcohol metabolism. They participate in life activities as coenzymes in many redox reactions in organisms and transform each other.
Under anaerobic conditions, very little ATP is produced from glucose metabolism. Under aerobic conditions, NADH or FADH2 produced through glycolysis and the tricarboxylic acid cycle can produce a large amount of ATP through the oxidative phosphate reaction. The amount of NADH is directly related to the amount of ATP produced. The more NADH each cell contains, the more energy it produces. The more energy an organ requires, the higher the amount of NADH it contains (or requires).
In May 2022, the latest research on NAD+ and aging by the Chinese scientific research team "Association of Human Whole Blood NAD+ Contents With Aging" (the relationship between NAD+ levels in human blood and aging) was published in the authoritative journal "Frontiers in Endocrinology". In this study, the Chinese scientific research team conducted the world's first large-scale correlation analysis between blood NAD+ (nicotinamide adenine dinucleotide) and age and gender in the Chinese population, and found that there are significant gender differences in the relationship between blood NAD+ levels and aging. , NAD+ levels in men decrease significantly with age, especially in middle-aged and elderly men.
What are the physiological functions of NADH?
1. Improve energy levels
NADH not only serves as an important coenzyme in aerobic respiration, but [H] of NADH also carries a large amount of energy. Research has confirmed that extracellular use of NADH can promote an increase in intracellular ATP levels, indicating that NADH can penetrate cell membranes and increase intracellular energy levels. From a macro perspective, exogenous supplementation of NADH helps restore physical strength and enhance appetite. And NADH's increase in brain energy levels also helps improve mental state and sleep quality. NADH has been used abroad to improve chronic fatigue syndrome, improve exercise endurance, and reduce jet lag.
2. Protect cells
NADH is a powerful antioxidant found naturally in cells. NADH can react with free radicals to inhibit lipid peroxidation and protect mitochondrial membranes and mitochondrial function. Studies have found that NADH can reduce oxidative stress in cells caused by various factors such as radiation, drugs, toxic substances, strenuous exercise, ischemia, etc., thus protecting vascular endothelial cells, liver cells, cardiomyocytes, fibroblasts, neurons, etc. Therefore, injected or oral NADH is clinically used in fields such as improving cardiovascular and cerebrovascular diseases and adjuvant cancer radiotherapy and chemotherapy. Topical NADH has been shown to be effective in treating rosacea and contact dermatitis.
3. Promote the production of neurotransmitters
Research shows that NADH significantly promotes the production of the neurotransmitter dopamine, a chemical signal critical for short-term memory, involuntary movements, muscle tone, and spontaneous physical reactions. It also mediates the release of growth hormone and determines muscle movement. Without enough dopamine, muscles become stiff. For example, Parkinson's disease is partly caused by disorders of dopamine synthesis in brain cells. Preliminary clinical trial data shows that NADH can help improve symptoms of Parkinson's disease. NADH can also promote the biosynthesis of norepinephrine and serotonin, showing good application potential for alleviating depression and Alzheimer's disease.
4. Safety of NADH
NADH has been tested for animal toxicity in rats and dogs. Even at high concentrations, NADH has no toxicity or side effects. NADH is approved as a nutritional supplement on Drug Bank, the world's largest and most complete resource library of drugs and drug targets. As a dietary supplement, NADH has been sold in the European and American markets for more than 20 years. According to the data contained in the FDA Adverse Event Reporting System (FDA Adverse Event Reporting System) and CFSAN Adverse Event Reporting System (CAERS Adverse Event Reporting System), there has never been a case of oral administration of NADH. Adverse events reported due to NADH. In 2018, CELFULL NADH of PURESSENCEBIO-TECH (USA) Inc. obtained the NPN (Natural Product Number, Canadian Natural Product Number) certificate issued by Health Canada.
5. Cell protection
Cell protection refers to the ability of certain substances to prevent or reduce damage to normal cells caused by toxic substances. Excessive cell damage will affect the functioning of biological organisms. Research shows that nuclear radiation, biological and chemical poisons can cause cell base damage, DNA chain breaks and protein cross-linking. Biological and chemical toxins not only act on DNA, but also directly act on the respiratory chain of mitochondria and the tricarboxylic acid cycle of biological oxidation. , by inhibiting the basic biological oxidative metabolic process in life activities, blocking energy supply, inducing apoptosis of normal human cells, causing disorder and destruction of normal physiological functions of the body. Therefore, cell protection has become a cutting-edge topic in life sciences and has important clinical significance. NADH is a coenzyme necessary for cellular energy metabolism. Its molecular weight is 709.4 and its isoelectric point is 3.0. Various activities of life phenomena and cell renewal, as well as the maintenance and balance of the entire life structure, all require energy, and NADH plays the role of electron transfer in biological processes.
Electrons in energy reactions are usually first transferred to NAD and then reduced to NADH. The electrons are transferred to oxygen through the transfer chain and release energy. Oxidative phosphorylation uses this energy to produce ATP. One molecule of NADH is reduced to produce 2.5 molecules of ATP. . NADH is mainly involved in the metabolism of carbohydrates, fats, and proteins. Since NADH activates multi-enzyme systems, promotes the synthesis and metabolism of nucleic acids, proteins, and polysaccharides, increases material movement and regulatory control, and improves metabolic functions, it is closely related to cell regeneration and Restoration and protection have a material basis. NADH plays an important role in maintaining cell growth, differentiation and energy metabolism. NADH is not only an important biochemical reagent, but may also play a cell protective role as a biochemical drug.
6. Autofluorescence
NADH exhibits autofluorescence in its reduced form, whereas NAD exhibits no fluorescence. This allows microscopic determination of the redox status of NAD(H) by measuring NADH fluorescence intensity, which has been shown to be relevant to cellular metabolic processes. Because the assessment of NADH autofluorescence is a label-free method, it has general in vivo applicability to many tissues such as skeletal muscle, brain, kidney, and skin.
Cellular redox status and NAD levels have been shown to play an integral role in cellular health. Therefore, NADH autofluorescence can provide insights into cellular metabolism, proton motive force, growth rate, and many other processes, and offer the potential for new therapeutic and diagnostic approaches. In the future, we may be able to determine multiple cellular parameters by measuring NADH fluorescence, which would be a true revolution in bioenergetics.
NADH preparation methods mainly include extraction, fermentation, fortification, biosynthesis and organic synthesis.
Package and delivery

Delivery
1-80kg	80-300kg	More than 300kg
More suitable for express transportation, door-to-door	More suitable for air transportation,airport-to-airport	More suitable for ocean transportation,port-to-port
7-10 days for delivery time	3-4 days for delivery time	20-40 days for delivery time

What service we can provide
Joyous Health provides Nicotinamide adenine dinucleotide(NADH） powder OEM services. We can customize formulas for customers, private labels, capsules, tablets, soft capsules and sachets, low MOQ, which is suitable for direct sales by brands. Our OEM product shipping channels are stable and delivery times are fast and worthy of customers' trust, we have served more than 300 brands.

Joyous Health Factory information and certifications
Xi'an Joyous Health Biotechnology Co., Ltd. was established in 2011. Over the past 12 years, Joyous Health has obtained ISO 9001, FDA, ISO 22000, and GMP certifications.
Joyous Health has an advanced laboratory to control quality, so that each batch of products undergoes strict testing, and has professional R&D personnel to provide customized product services.
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