Name: Ergothioneine
Brand: Joyous Pellets Supplement raw materials, cosmetic ingredients, weight
Availability: InStock
Rating: 5 (1 reviews)

Ergothioneine is a natural antioxidant that can protect cells in the human body. Ergothioneine is an important active substance in the body. Ergothioneine has many physiological functions such as scavenging free radicals, detoxifying, maintaining DNA biosynthesis, normal cell growth and cellular immunity.

Product Name

L-Ergothioneine

Appearance

White crystalline powder

Specification

99%

CAS No

497-30-3

Molecular Formula

C9H15N3O2S

Package

25kg cardboard drum

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Desciption

Product information
What is Ergothioneine powder?
Ergothioneine (mercaptohistidine trimethyl internal salt, ergothioneine, EGT) is a compound discovered in 1909. It was first discovered in a fungus, Claviceps purpurea. The pure product is white crystal, water-soluble, (at room temperature Soluble 0.9mol/L), it will not oxidize itself under physiological pH value and strong alkaline solution. It exists in two isomers, namely thiol and thione forms, as shown in the picture on the right.
Ergothioneine is a natural antioxidant that can protect cells in the human body and is an important active substance in the body. Natural antioxidants are safe and non-toxic and have become a hot research topic. Ergothioneine, as a natural antioxidant, has entered people's field of vision. It has many physiological functions such as scavenging free radicals, detoxifying, maintaining DNA biosynthesis, normal cell growth and cellular immunity.
Joyous Ergothioneine powder specification

Terms	Standard	Terms	Standard
Product Name	Ergothioneine	Appearance	White powder
Assay	99%	Loss on Drying	≤2%
Total Heavy Metals	≤10 ppm	Ash	≤2%
As	≤0.5ppm	Total Plate Count	≤750 cfu/g
Pb	≤0.5ppm	Yeast and Mold	≤100 cfu/g
Cd	≤0.5ppm	Coliforms	Negative
Hg	≤0.1ppm	E.Coli	Negative
Packing	Pack in 25kgs paper-drums, inner by double plastic bag	Shelf life	24 months under the above condition, and in its original package

Distribution range of ergothioneine
Ergothioneine is distributed in some tissues and organs of mammals, mainly in red blood cells (about 1 to 2 mmol.L) and the semen of some animals. Although there are no experimental studies showing that any animals can synthesize this substance, There must be pathways within animal cells for the uptake and retention of ergothioneine. For carnivores, ergothioneine in animal tissues can supply dietary needs. Melville.D.B and Eich. S found that ergothioneine also exists in cereal plants. Subsequent research by Melville.D.B and Genghof.D.S showed that ergothioneine is a common component of many microbial cells and can be synthesized in several fungi, but not in bacteria. Edible fungi such as delicious porcini, mushrooms, and Coprinus can produce the precursor histidine trimethyl internal salt (hercynine) required for the synthesis of ergothioneine; and Coprinus can also produce ergothioneine and other rare amino acids.
Preparation method of ergothioneine
There are three methods for preparing ergothioneine: chemical synthesis, extraction and biological fermentation synthesis.
It is very difficult to synthesize levorotatory ergothioneine chemically. Several synthesis methods have not achieved the expected yield due to partial or complete racemization. The difficulty of synthesis is that it is difficult to prepare the raw material 2-mercaptoimidazole, and the acidity of the α-position carbon This will make the reaction prone to racemization. OXIS International was the first to develop an efficient and commercial method for synthesizing ergothioneine and applied for a patent in 1995. The method is to introduce sulfhydryl groups into the imidazole ring. However, it is difficult to guarantee the safety of chemically synthesized products. The synthetic raw materials are expensive, the synthesis cost is high, and the selling price of the products is high, which limits the application of ergothioneine.
The natural biological extraction method extracts ergothioneine from the fruiting bodies of edible fungi, pig blood, animal tissues, ergot and grains. However, the content of ergothioneine in the above raw materials is still very low, and there are many impurities in the raw materials and drug residues. Problems such as high extraction costs limit the application of ergothioneine and are not suitable for industrialization;
The biosynthetic preparation of ergothioneine using mushroom mycelium submerged fermentation technology is the mainstream direction for low-cost large-scale production of ergothioneine. It can effectively increase the yield of ergothioneine and reduce production through fermentation process control methods such as metabolic regulation. The cost, and more importantly, can ensure the safety of the product and broaden the application space of ergothioneine.
Biological functions and effects of ergothioneine
⑴Anti-aging effect
⑵Prevent cancer
⑶Detoxification effect
⑷Maintain DNA biosynthesis
⑸Maintain normal cell growth
⑹Maintain cellular immune function
⑺Other functions
Anti-oxidize effect
Ergothioneine is a natural amino acid derived from plants and can be accumulated in animals. Research has proven that it has the effect of an antioxidant. It can effectively remove -OH, chelate divalent iron ions and copper ions, and prevent H2O2 -OH is generated under the action of iron ions or copper ions, which can also inhibit the copper ion-dependent oxidation of oxyhemoglobin. It can also inhibit the peroxidation of arachidonic acid after myoglobin (or hemoglobin) is mixed with H2O2. reaction. Ergothioneine can also powerfully scavenge hypochlorous acid, thus preventing the inactivation of α1-antiprotease. However, it cannot inhibit the peroxidation reaction of lipid particles in the presence of iron ions. Studies by AKanmu D and others have shown that a certain concentration of ergothioneine in the body can act as an antioxidant.
protective effect on cells
Ergothioneine is a powerful scavenger of hypochlorous acid (HOCl). Although many compounds can react with hypochlorous acid, few react as quickly as ergothioneine. a 1-Antiprotease inhibitors (API), such as elastase, are particularly sensitive to hypochlorous acid, and physiological concentrations of ergothioneine can very effectively protect API against the inactivation caused by hypochlorous acid. Neutrophils are the main source of hypochlorous acid in the body, and one of the functions of ergothioneine is to protect red blood cells from neutrophils that come from normally functioning or pathologically inflammatory sites.
anti-inflammatory effect
Peroxynitrite is endogenously formed by the limited diffusion reaction of NO and superoxide. It is a strong oxidant related to the pathophysiology of inflammation, such as ischemia-reperfusion injury, atherosclerosis, acute pneumonia and sepsis. Ergothioneine can inhibit peroxynitrite anion-mediated amino acid oxidation, such as nitration of tyrosine, thereby providing feasibility for the treatment of inflammation.
Other biological functions
Since the discovery of ergothioneine, many attempts have been made to elucidate its physiological functions, but none has been able to completely define its physiological functions. Brummel.m.c research found that ergothioneine may also have the following functions: transporting cations and catalyzing carbon dioxide carboxylation or decarboxylation reactions; regulating thyroid and anti-thyroid effects; regulating histamine or antihistamine effects; cholinergic function or Anti-parasympathetic physiological effects; can regulate the reactivity of other acyl carriers or act as an acid carrier itself. Epand R M et al also studied the effect of ergothioneine on diabetes.
It has strong antioxidant activity: scavenging reactive oxygen species, chelating divalent metal ions, activating antioxidant enzymes, inhibiting superoxide dismutase, inhibiting oxidation reactions of various heme proteins, etc. Due to these properties of ergothioneine, it has a wide range of uses and market prospects in the fields of medicine, food and beverages, functional foods, animal feed, cosmetics and biotechnology.
Metabolism
Research has shown that ergothioneine cannot be synthesized in animals, but it has been clearly shown that histidine, the sulfuratom, and the methyl groups of methionine can be synthesized (incorporate into) in plants and microorganisms. D. Yanasugondha and M.D. Appleman studied the catabolism of ergothioneine in microorganisms. They found that ergothioneine can be converted into trimethylamine and thiol imidazole acrylic acid; Heath fed rats containing [S]ergothioneine for 21 days. After eating the food, it was found that ergothioneine with [S] label was distributed in bone marrow, red blood cells, liver, kidney and other parts. George Wolf and others first injected [α-S]ergothioneine into rats, and then studied the distribution of radioactive energy and its metabolites. It was proved that herzynine is the precursor (precursor) for the synthesis of ergothioneine.
Applications of Ergothioneine
As for ergothioneine, a substance with significant and unique biological functions, scholars from various countries have long conducted research on its application. Although it still needs to be further deepened, it has played a very inspiring role in its application in various fields. Ergothioneine has a wide range of uses and market prospects in the fields of organ transplantation, cell preservation, medicine, food and beverages, functional foods, animal feed, cosmetics and biotechnology.
Acts as a unique antioxidant
Ergothioneine is a highly protective, non-toxic natural antioxidant that is not easily oxidized in water, allowing its concentration to reach mmol in some tissues and stimulating the cell's natural antioxidant defense system. . Among many antioxidants, ergothioneine is particularly unique because ergothioneine can chelate heavy metal ions and protect red blood cells in the body from free radical damage.
for organ transplantation
The amount and duration of preservation of existing tissue play a decisive role in the success of organ transplantation. The most commonly used antioxidant in preserving organ transplants is glutathione. When it is exposed to the environment, it is easily oxidized. Even in refrigerated or liquid environments, its antioxidant capacity is greatly reduced and it is toxic to cells. It also produces inflammation and induces hydrolysis of tissue proteins. Ergothioneine is like an antioxidant that is stable in aqueous solution and can also chelate heavy metal ions. In the field of organ protection, it can be used as a substitute for glutathione to better protect transplanted organs.
Added to cosmetics as skin protectant
Ultraviolet UVA in the sun can penetrate into the dermis of human skin, affecting the growth of epidermal cells, causing surface cells to age and die, causing premature aging of the skin, while ultraviolet UVB can easily lead to the occurrence of skin cancer. Ergothioneine can minimize the formation of reactive oxygen species and protect cells from radiation damage. Therefore, ergothioneine can be added to some cosmetics as a skin protectant to develop outdoor skin care products and protective cosmetics.
Applications in ophthalmology
In recent years, studies have found that ergothioneine plays a key role in eye protection. Therefore, many researchers hope to develop an ophthalmic product to promote the development of ophthalmic treatment surgeries. Ophthalmic surgeries are generally performed locally, and the water solubility and stability of ergothioneine provide the feasibility of such surgeries and have great application value.
Applications in other areas
Ergothioneine can be used in many fields due to its excellent properties. For example, it is used in the fields of medicine, food, health products, cosmetics, etc. In the field of medicine, it can be used to treat inflammation, etc., and can be made into tablets, capsules, oral preparations, etc.; in the field of health products, it can prevent the occurrence of cancer, etc., and can be made into functional foods, functional drinks and other products. In the field of cosmetics, it can be used to treat inflammation, etc. It is used for anti-aging and can be made into sunscreen and other products.
As people's awareness of health care increases, the excellent properties of ergothioneine as a natural antioxidant will slowly be widely recognized and applied.
Package and delivery

Delivery
1-80kg	80-300kg	More than 300kg
More suitable for express transportation, door-to-door	More suitable for air transportation,airport-to-airport	More suitable for ocean transportation,port-to-port
7-10 days for delivery time	3-4 days for delivery time	20-40 days for delivery time

What service we can provide
Joyous Health provides ergothioneine powder OEM services. We can customize formulas for customers, private labels, capsules, tablets, soft capsules and sachets, low MOQ, which is suitable for direct sales by brands. Our OEM product shipping channels are stable and delivery times are fast and worthy of customers' trust, we have served more than 300 brands.

Joyous Health Factory information and certifications
Xi'an Joyous Health Biotechnology Co., Ltd. was established in 2011. Over the past 12 years, Joyous Health has obtained ISO 9001, FDA, ISO 22000, and GMP certifications.
Joyous Health has an advanced laboratory to control quality, so that each batch of products undergoes strict testing, and has professional R&D personnel to provide customized product services.
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Where to buy ergothioneine powder?
We offer the best ergothioneine powder at the most competitive price.Ergothioneine Powder bulk and wholesale powder have been 3rd lab-tested and verified for both product purity and identity.
We also provide ergothioneine powder in bulk order or wholesale according to client needs. Just submit the requirements in the bottom form, we will reply soon!

Contacts: Faith Feng
Email:faith@joyouspellets.com
Tel and Whatsapp:+86 17391747738

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